Following up on this finding, all of us investigated the alignments meant for the remaining four patients and detected a recurrent 5-bp insertion in every 4 . The mutations in CALR that were found by means of whole-exome sequencing were confirmed and been shown to be somatic through Sanger sequencing of the granulocyte and matched T-lymphocyte DNA samples from all six individuals. CALR Exon 9 Mutations in Myeloproliferative Neoplasms To estimate the prevalence of CALR mutations in myeloproliferative neoplasms, we screened a cohort of 896 sufferers for insertion or deletion mutations in CALR exon 9 .The project’s total spending budget is EUR 8.5 million, of which the EU’s contribution is EUR 6 million. The contractual negotiations will end up being concluded soon, in January 2009 and the project will start. About VTT Technical Analysis Center of Finland VTT Complex Research Center of Finland may be the biggest contract research organization in Northern Europe. VTT provides high-end technology solutions and innovation services. From its wide understanding foundation, VTT can combine different technology, create new improvements and a substantial range of world-class technology and applied research services, thus improving its clients’ competitiveness and competence.