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However the Tartars used it to gain military advantage; they catapulted cadavers of the deceased into the city, which resulted in an outbreak of plague there then. That forced the Genoese forces to retreat. An epidemic of plague, known also as the Dark Death, followed and continued to sweep through Europe, the Near North and East Africa through the 14th century. It’s been called the most severe pandemic in recorded history. The siege of Caffa can be a robust reminder of the terrible consequences when illnesses are used as weapons, said the review. The 14th century plague killed a lot more than 25 million Europeans, and there were other instances where disease and poisons were used during warfare, the historic review said.