.. African American patients more likely to get replacement surgery in low-quality hospitals Study reveals proof racial disparities in access to hospitals that perform high-quality joint substitute careRacial minorities have reduced usage of high-quality joint replacement treatment, according to Dr. Xueya colleagues and Cai from the University of Iowa in america. Their work, published on-line in Springer’s journal Clinical Orthopaedics and Related Analysis, implies that African American individuals are more likely than Caucasians to get total knee arthroplasty in low-quality hospitals. Total joint arthroplasty is broadly performed in sufferers of most races with severe osteoarthritis to relieve discomfort and improve joint function and mobility.THE ANALYSIS This was an open-label dose-escalating Phase 1 trial to assess toxicity and efficacy of perifosine, given in monotherapy to individuals with neuroblastoma . Disease evaluation was every eight weeks.7 years and a median disease duration of 4.6 years . Three patients were treated for neuroblastoma refractory to main therapy, and 21 for neuroblastoma resistant to salvage therapy after 1 to 5 prior relapses. Therapy included high-dose typical induction Prior and 2nd collection chemotherapy ; myeloablative stem and chemotherapy cell transplantation and/or targeted radiotherapy with I-131-MIBG . No significant toxicity was seen, in particular no grade 3 problems, and no safety issues were encountered in 6 patients who began treatment with pre-existing thrombocytopenia and/or quality 3 elevations in liver enzymes.