Weather data from the Australian Bureau of Meteorology were sourced for the duration of the study period. Researchers compared the weather at that time patients 1st noticed back discomfort with climate one week and a month prior to the onset of discomfort . Results demonstrated no association between back temperature and pain, humidity, atmosphere pressure, wind precipitation or direction. However, higher wind quickness and wind gusts did slightly raise the chances of lower back pain, but the amount of increase was not clinically important. ‘Our results refute previously held beliefs that one common weather conditions increase risk of lower back discomfort,’ concludes Dr. Steffens. ‘Further investigation of the influence of weather parameters on symptoms connected with specific illnesses such as fibromyalgia, arthritis rheumatoid, and osteoarthritis are needed.’..Clinically relevant nonmajor bleeding is an important factor to consider, since its administration is time-consuming and costly16 and since bleeding may be the most important reason for the perception of decreased health and quality of life among patients treated with warfarin.17 In trials of the only available oral direct thrombin inhibitor previously, ximelagatran, noninferiority regarding warfarin was achieved in the treatment of recurrent venous thromboembolism, and rates of main bleeding were comparable in both treatment groups.18 However, toxic results to the liver occurred with prolonged contact with ximelagatran.19 In contrast, there was no evidence of hepatic toxic events associated with dabigatran in the current study or in studies where it was useful for other indications.7,8,20 Dyspepsia, that was seen in 3 percent of the sufferers in the dabigatran group, was the only real adverse event due to dabigatran inside our study.