The mature plaque can offer the perfect environment for cross-presentation.

We therefore concluded that we could use a bone marrow transplantation approach to efficiently disturb cross-presentation in atherosclerosis. In order to investigate the relative contribution of Batf3-dependent cross-presentation in progression and development of atherosclerosis, lethally irradiated ldlr mice were reconstituted with bone marrow from batf3 mice or wild type control mice. After recovery, mice were given a Western type diet for 10 weeks to induce atherosclerotic plaque formation . 3d), because their development is Batf3 dependent also. Illustrating specificity of the batf3 model, other leukocyte populations in blood , spleen or peripheral lymph nodes were not affected.Understanding the unique health concerns this populace faces is central to enhancing quality of life for survivors today as well as improving treatments for the next generation of patients. Related StoriesMD Anderson study reveals why chemotherapy medications not effective for many pancreatic cancer patientsViralytics enters into clinical trial collaboration agreement with MSDNew antenna-like device makes breast cancer surgery less difficult for surgeonsAt St. Jude, Robison is chair of the Division of Tumor and Epidemiology Control; associate director for Cancer Avoidance and Control in the Tumor Center; and co-leader of the Malignancy Control and Prevention Plan.