Therefore EHRs will be only as good as the quality metrics they’re made to capture; technology can’t overcome fundamental measurement issues. We measure many things that have no worth to patients, while much of what individuals do value, including our interest, remains unmeasurable. Why, Wachter asks, perform we do nothing equivalent in health care? In a moving passage, Wachter speaks with a renowned surgeon who once spent his evenings before surgery reading his notes on the next day’s patients. No longer. His notes have already been rendered homogeneous by the tyranny of clicks and auto-populated fields uselessly.Like JAK2 mutations in the full case of polycythemia vera,30 mutations in FOXL2 are present in a large most adult-type granulosa-cell tumors and involve an individual base substitution. Cys 134 is located on the surface of the forkhead DNA-binding domain; modeling shows that the substitution of tryptophan for cysteine does not disrupt the folding of this domain or its interactions with DNA . We speculate that its pathogenicity is usually imparted through various other mechanisms therefore, like the altering of one or more interactions between FOXL2 and other proteins.