There is no disease-modifying drug for osteoarthritis. Mild and moderate symptoms may be attentive to nonpharmacological interventions or basic analgesics, but many patients holiday resort to anti-inflammatory medications. Arthroscopic debridement includes a specific and limited part for the treatment of osteoarthritis. Abrasive arthroplasty yields also less predictable outcomes and is not generally recommended. Some 20 to 30 percent of patients treated by high tibial osteotomy need conversion to a total knee replacement.Slutsky, M.D., and Maureen O. Meade, M.D. For the OSCILLATE Trial Investigators and the Canadian Essential Care Trials Group: High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome The acute respiratory distress syndrome is a common complication of critical illness.1,2 Mortality is high, and survivors frequently have long-term complications.3,4 Although mechanical ventilation is life-sustaining for patients with ARDS, it could perpetuate lung injury.