All patients provided written educated consent for participation. The study was created by the authors and monitored by an independent data and basic safety monitoring committee. The SWOG Cancer Analysis Group coordinated the study and was responsible for the design of the study and the collection, analysis, and reporting of the info. The authors attest to the accuracy and completeness of the reported data and for the fidelity of the analysis to the protocol, which is obtainable with the entire text of this content at NEJM.org. Eligible individuals had taken no estrogens, antiestrogens, selective estrogen-receptor modulators, aromatase inhibitors, or hormonal contraceptives within the month before enrollment. Exceptions were made for the usage of hormonal contraception in ladies younger than 35 years that was discontinued before randomization and for hormonal treatment for 2 weeks for the purposes of in vitro fertilization and cryopreservation of embryos or oocytes before randomization.Using its scale and leadership positions in the region, strong commercial and development organizations, well-respected leadership team and a reliable portfolio of regarded brands, CFR is among the leading top quality generic companies in Latin America, stated Miles D. Light, chairman and chief executive officer, Abbott. This acquisition will considerably improve and broaden Abbott's Latin American footprint, and is well aligned with this long-term strategy and dedication to fast-growing markets. Abbott expects the acquisition to add approximately $900 million to its sales in the first full calendar year , with anticipated double-digit sales development over the next several years.