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Found specific EGFR mutations that correlated with tumor response to gefitinib.7 In the Iressa Survival Evaluation in Lung Malignancy trial , the target response price for gefitinib-treated patients was 37.5 percent among the 16 patients with a tumor bearing an EGFR mutation in comparison with 2.6 percent among the 116 patients with out a mutation. The difference in the rates of objective response between gefitinib-treated individuals with an EGFR mutation and those lacking any EGFR mutation was remarkable. The rate of a target response to first-range gefitinib in our study is similar to prices reported in other studies in which sufferers were selected relating to EGFR-mutation status, including sufferers in Western countries.10,12,28 Sequist et al. Screened patients for an EGFR mutation and reported a target response rate of 54.8 percent among 31 gefitinib-treated individuals who were positive for an EGFR mutation, only 2 of whom were Asian.12 However, in our study, goal response rates among patients lacking any EGFR mutation were less than expected, given the results of previous studies.16,29 One possible explanation is our use of ARMS, a more sensitive way of detecting EGFR mutations.21,22 When Zhu et al.