In this study, we have recognized two novel somatic gain-of-function mutations in HIF2A in multiple tumors from two individuals presenting with paraganglioma connected with polycythemia. Our findings suggest that the clinical presentation in these individuals may stand for a syndrome initiated by gain-of-function mutations in HIF2A. Case Reports Patient 1 A 30-year-old girl was referred for evaluation of recurrent, multiple, or metastatic paragangliomas. The individual had acquired polycythemia since infancy. At age 14 years, she was found to have a left paraaortic paraganglioma, and at the age of 15 years, yet another aortocaval paraganglioma was detected.Istanbul, the administrative centre of Turkey is certainly one of them. Besides, hair transplantation is being done in Kosten, Haartransplantation Kosten is reported to be one of the best in Turkey. Here the clinics are served by experienced and skilful hair transplant surgeons highly, who would be sure that your requirements are met. Fue Hair Transplantation One of the most popular and effective form of hair transplantation is normally Fue Haartransplantation. In this technique one donor is needed who voluntarily donate hair. In this process, the hairs extracted from the donor are fixed on the scalp using highly modern and advanced equipment.