Alarm raised over preoperative hyponatremia By Eleanor McDermid.

‘Increased risk in individuals scheduled for elective medical procedures with mild and almost certainly asymptomatic hyponatremia presents a significant opportunity for the internist carrying out preoperative medical consultation,’ state DuPree and Vassalotti. They add that the high prevalence of slight, and asymptomatic presumably, hyponatremia highlights the need for determining the underlying etiology. Hyponatremia also raised the chance for perioperative complications. Patients with the problem had a 21 percent elevated risk for major coronary events, a 24 percent elevated risk for wound attacks, and a 17 percent rise in the chance for developing pneumonia.Oxford BioMedica’s Chief Executive Officer, John Dawson, commented: The effective completion of the first stage of the collaboration is testament to the quality of the scientific groups at the ALS TDI and Oxford BioMedica. Our LentiVector technology has unique capabilities to provide genes and efficiently to neuronal cells and our product candidate securely, MoNuDin, has shown promising outcomes in preclinical models of ALS. The expansion of our collaboration with the ALS TDI allows us to accelerate MoNuDin’s development and to explore fresh disease pathways as potential targets for genetic intervention.