Dosages were reduced to 720 mg or 480 mg daily twice, depending on the intensity of the event. Dermatologic evaluations for cutaneous squamous-cell carcinoma were performed regularly, and any lesions discovered were surgically excised. Although this disease is known as a quality 3 toxic effect according to the CTCAE, affected patients were permitted to continue treatment without dose decrease or interruption. Statistical Analysis The principal efficacy end point was the overall response rate as assessed by the IRC.In light of this, patients should be reminded that the FDA specifications for supplements are much weaker compared to the standards for authorized drugs. Potential adverse side effects might not be listed on a natural supplement&rsquo even;s label, and there is prospect of supplements to dangerously connect to certain medications also. Coenzyme and Melatonin Q10 supplements, for instance, can reduce the anticoagulant ramifications of warfarin, and supplements such as cinnamon, chromium, and whey proteins can exacerbate the consequences of hypoglycemic drugs.