The mole was absent in baseline photographs taken two years prior to the consultation. Dermoscopy exposed a symmetrical lesion that acquired a well developed pigment network with a uniform pattern. Excision biopsy demonstrated an epidermis with a well produced pigmented rete ridge system associated with increased single melanocytes and nests of melanocytes that were not really confluent. The higher dermis demonstrated scattered lymphocytes and some melanin pigment .. A mole of latest onset This is another full case to help you hone your skills in dermoscopy.Menarche occurred at the age of 10 years and preceded chronic oligomenorrhea. She acquired 10 miscarriages of unknown trigger and two full-term pregnancies complicated by hypertension. Both her daughters experienced a generally muscular appearance and peripheral lipoatrophy , with unaltered faciocervical excess fat, and axillary acanthosis nigricans . They had hypertriglyceridemia from late puberty , and liver steatosis was noted on ultrasonographic imaging. Peripheral lipoatrophy was confirmed by skinfold-thickness measurements , and a lower life expectancy extra fat mass with an increased lean mass was documented on dual-energy x-ray absorptiometry in all three patients .14 Patient 2 Patient 2, a 50-year-old woman of self-reported white, French ancestry, was first evaluated when she was 25 years because of her cushingoid appearance, reported as having been present since childhood.